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The pragmatism idea is controversial and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. 무료 프라그마틱 suggested a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, as well as the follow-up. There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.